Publications
2025
Chahat Mehra, Jesús Alvarado Valverde, Ana Margarida Nogueira Matias, Francesca Torelli, Tania Catarina Medeiros, Julian Straub, Peter Bradley, Katja Luck, Steffen Lawo, Moritz Treeck, Lena Pernas. Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection.(2025) Nature Microbiology
Tania C. Medeiros, Jana Ovciarikova, Xianhe Li, Patrick Krueger, Tim Bartsch, Silvia Reato, Jack Crow, Michelle Tellez Sutterlin, Bruna Martins Garcia, Irina Rais, Kira Allmeroth, Matías D. Hartman, Martin S. Denzel, Martin Purrio, Andrea Mesaros, Kit-Yi Leung, Nicholas D.E. Greene, Lilach Sheiner, Patrick Giavalisco, and Lena Pernas. Mitochondria protect against an intracellular pathogen by restricting access to folate.(2025) Science.
Perspective:
Mitochondria hoard folate to starve a parasite. Suomalainen A. & Nikkanen J. (2025)
Science Coverage:
Scientists discover how cells use a secret weapon to fight off some pathogens.
Mitochondria defend cells against pathogens.
2024
Bruna. M. Garcia, Phillip. Melchinger, Tania. C. Medeiros, S. Hendrix, Kavanh. Prabhu, Mauro. Corrado, J. Kingma, A. Gorbatenko, Soni. Deshwal, M. Veronese, Luca. Scorrano, Erika. Pearce, Patrick. Giavalisco, Noah. Zelcer, Lena. Pernas. Glutamine sensing licenses cholesterol synthesis.(2024) EMBO.
2021
Xianhe Li, Julian Straub, Tania C. Medeiros, Chahat Mehra, Fabian den Brave, Esra Pekker, Ilian Atanassov, Katharina Stillger, Jonas Benjamin Michaelis, Emma Burbridge, Colin Adrain, Christian Münch, Jan Riemer, Thomas Becker, LenaF. Pernas. Mitochondria shed their outer membrane in response to infection-induced stress.(2021) Science.
2019 and earlier
Rongfeng Cui, Tania Medeiros, David Willemsen, Leonardo N.M. Iasi, Glen E.Collier, Martin Graef, Martin Reichard, Dario Riccardo Valenzano. Relaxed Selection Limits Lifespan by Increasing Mutation Load. (2019) Cell.
Tania C. Medeiros, Ryan Thomas, Ruben Ghillebert, Martin Graef. Autophagy balance mtDNA synthesis and degradation by DNA polymerase gamma during starvation. (2018) J Cell Biol.
Vitor Teixeira, Tania C. Medeiros, Rita Vilaca, Joana Ferreira, Pedro Moradas-Ferreira, Vitor Costa. Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells. (2016) Biochim Biophys Acta.
Vitor Teixeira, Tania C. Medeiros, Rita Vilaca, Andreia T. Pereira, Susana R. Chaves, Manuela Corte-Real, Pedro Moradas-Ferreira, Vitor Costa. Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells. (2015) Cell Signal.
Vitor Teixeira, Tania C. Medeiros, Rita Vilaca, Pedro Moradas-Ferreira, Vitor Costa. Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells. (2014) Microb Cell.
Reviews & Comentary
Tania C. Medeiros, Chahat Mehra, Lena F. Pernas. Contact and competition between mitochondria and microbes.(2021) Curr Opin Microbiol.
Tania C. Medeiros and Martin Graef. Autophagy determines mtDNA copy number dynamics during starvation. (2019) Autophagy.